MYC Inhibition Potentiates CD8+ T Cells Against Multiple Myeloma and Overcomes Immunomodulatory Drug Resistance.

Lorraine N Davis Zachary J Walker Lauren T Reiman Sarah E Parzych Brett M Stevens Craig T Jordan Peter A Forsberg Daniel W Sherbenou

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study supports the concept that MYC represents an Achille's heel in MM across disease states and that MYCi975 may be a promising therapeutic for patients with MM, particularly in combination with IMiDs.

Keyphrases

multiple myeloma
transcription factor