Performance comparison of a flow cytometry immunoassay for intracellular cytokine staining and the QuantiFERON® SARS-CoV-2 test for detection and quantification of SARS-CoV-2-Spike-reactive-IFN-γ-producing T cells after COVID-19 vaccination.
Nuria TormoEstela GiménezMaría Martínez-NavarroEliseo AlbertDavid NavalpotroIgnacio TorresConcepción GimenoDavide NavarroPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2022)
The data suggest a greater sensitivity for the FC-ICS assay than the QF test, and urge caution when comparing SARS-CoV-2 T-cell immune responses assessed using different analytical platforms.