Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila.
Eric M SawyerElizabeth C BrunnerYihharn HwangLauren E IveyOlivia BrownMegan BannonDennis AkrobetuKelsey E SheafferOshauna MorganConroy O FieldNishita SureshM Grace GordonE Taylor GunnellLindsay A RegrutoCricket G WoodMargaret T FullerKaren G HalesPublished in: BMC cell biology (2017)
We demonstrate the first known instance of a tissue-specific ATP synthase subunit affecting tissue-specific mitochondrial morphogenesis. Since ATP synthase dimerization is known to affect the degree of inner mitochondrial membrane curvature in other systems, the effect of Knon and other testis-specific paralogs of ATP synthase subunits may be to mediate differential membrane curvature within the Nebenkern.
Keyphrases