Possible genetical predictors of efficacy and safety of budesonide-MMX in patients with mild-to-moderate ulcerative colitis, and safety comparison with methylprednisolone.

Tamás ResálKatalin MangóPéter Bacsur Kata Judit SzántóDaniella PigniczkiCsilla KeresztesMariann Rutka Anita BálintÁgnes MilassinRenáta Bor Anna FábiánZoltán SzepesKlaudia FarkasKatalin MonostoryTamás Molnár

Published in: Expert opinion on drug safety (2023)

CYP genotypes can affect the efficacy of budesonide-MMX; however, further studies would be needed with analyses of gene expression. Although budesonide-MMX is safer than methylprednisolone, due to glucocorticoid-related side effects, admission should require greater precaution.

Keyphrases

gene expression
ulcerative colitis
high dose
emergency department
dna methylation
low dose
case control
drug induced