Conductive phthalocyanine-based porous organic polymer as sensing platform for rapid determination of vanillin.

Vanillin (Van) is widely utilized in processed foods and medicines for its appealing scent and multiple therapeutic benefits. However, its overconsumption poses a risk to public health, making its quantification essential for ensuring food and medicine safety and quality. This study introduces a stable and conductive phthalocyanine-based porous organic polymer (NiPc-CC POP), synthesized through a straightforward electrophilic substitution of nickel tetra-amine phthalocyanine (NiTAPc) with cyanuric chloride (CC). Appropriate characterization techniques were employed to determine the morphologies and structures of the synthesized materials. Furthermore, the NiPc-CC POP was applied to devise a sensitive Van detection method. Leveraging the high electrocatalytic activity of NiPc-CC POP toward Van oxidation, a linear response of 0.15-32 μmol L -1 was achieved, along with an exceptional detection limit of 0.10 μmol L -1 . The sensor demonstrated high selectivity and stability. Samples of human serum and tablets spiked with Van were analyzed, yielding satisfactory recoveries. Consequently, this work contributes to the advancement of sensitive detection platforms for Van at minimal concentrations.