The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs.
Mariska P M van den BergSusan Nijboer-BrinksmaI Sophie T BosMaarten van den BergeDavid LambMartijn van FaassenIdo P KemaReinoud GosensLoes E M KistemakerPublished in: Respiratory research (2021)
TRPA1 inhibition protects against AHR and the EAR and LAR in vivo and allergen and histamine-induced airway narrowing ex vivo, and reverses allergen-induced bronchoconstriction independently of inflammation. This effect was partially dependent upon histamine, suggesting a neuronal and possible non-neuronal role for TRPA1 in allergen-induced bronchoconstriction.