Influence of the cumulative effect of zoledronic acid on periodontal microcirculation in rats.
G A KosachA L PetrosyanAndrei I IaremenkoS I KutukovaA A ZubarevaS G ChefuT D VlasovPublished in: Oral and maxillofacial surgery (2021)
The introduction of ZA in a dose-dependent fashion resulted in impaired endothelial vasodilation and impaired blood flow to extraction sockets. These findings might explain the development of osteonecrosis of the mandible following removal of a first molar.
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