Continued Increase of Erythromycin- and Clindamycin-Nonsusceptibility among Invasive Group A Streptococci Driven by Genomic Clusters, USA, 2018-2019.

Yuan LiJoy RiversSaundra MathisZhongya LiLesley McGeeSopio ChochuaBenjamin J MetcalfKatherine E Fleming-DutraSrinivas A NanduriBernard Beall

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

We analyzed 9630 invasive Group A Streptococci (iGAS) surveillance isolates in the USA. From 2015-2017 to 2018-2019, significant increases in erythromycin-nonsusceptibility (18% vs. 25%) and clindamycin-nonsusceptibility (17% vs. 24%) occurred, driven mainly by rapid expansions of genomic subclones. Prevention and control of clustered infections appear key to containing antimicrobial resistance.

Keyphrases

antimicrobial resistance
copy number
public health
dna methylation
loop mediated isothermal amplification
quantum dots