Antiseizure medications as migraine preventatives: a call for action for a teratogenic and neurodevelopmental risk removal.

William David Wells-Gatnik Paolo Martelletti

Published in: Expert opinion on drug safety (2023)

The use of valproate and topiramate in women of childbearing potential should be highly discouraged. Our recommendations include a review of current prescribing guidelines, further public education regarding the neurodevelopmental and congenital risks associated with the use of valproate and topiramate, and an appeal for further research defining the safety of alternative medications for migraine prevention when intrauterine exposure is possible.

Keyphrases

healthcare
clinical practice
human health
primary care
polycystic ovary syndrome
adverse drug
congenital heart disease
quality improvement
risk assessment
breast cancer risk
emergency department
climate change
pregnant women
electronic health record