Innate immune responses against the fungal pathogen Candida auris.
Yuanyuan WangYun ZouXiaoqing ChenHao LiZhe YinBao-Cai ZhangYongbin XuYiquan ZhangRulin ZhangXinhua HuangWenhui YangChaoyue XuTong JiangQinyu TangZili ZhouYing JiYingqi LiuLingfei HuJia ZhouYao ZhouJingjun ZhaoNingning LiuGuanghua HuangHaishuang ChangWenxia FangChangbin ChenDongsheng ZhouPublished in: Nature communications (2022)
Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.
Keyphrases
- candida albicans
- cell wall
- immune response
- biofilm formation
- multidrug resistant
- innate immune
- endothelial cells
- acinetobacter baumannii
- drug resistant
- dendritic cells
- gram negative
- methicillin resistant staphylococcus aureus
- induced pluripotent stem cells
- staphylococcus aureus
- high resolution
- atomic force microscopy
- infectious diseases