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Visible-Light-Mediated Synthesis of α-Aryl Ester Derivatives via an EDA Complex.

Yutong LiuShuangqiao LiXueqin ChenHe-Zhong Jiang
Published in: The Journal of organic chemistry (2023)
We report an efficient radical-based and photocatalyst-free method for the C(sp 2 )-C(sp 3 ) cross-coupling reaction to synthesize α-aryl ester derivatives. The process starts from a β-keto ester and an electron-deficient halogenated aryl halide under alkaline conditions to form an electron donor-acceptor complex and is driven by visible light. From the synthetic point of view, this newly established method represents a simple way to access arylpropionic acids from commercially available and cheap starting materials.
Keyphrases
  • visible light
  • solar cells
  • electron transfer
  • anaerobic digestion
  • wild type