Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18 F-FDG positron emission tomography.
Stephen RankinCaitlin FountainAlastair J GemmellDaire QuinnAlasdair D HendersonJohn McClureSandy SmallBalaji VenugopalPamela McKayPiotr J SlomkaDavid ColvilleMark Colquhoun PetrieGiselle C MeléndezNinian N LangPublished in: bioRxiv : the preprint server for biology (2024)
In a large animal model, anthracycline exposure was associated with aortic fibrosis. In patients with lymphoma, anthracycline exposure was not associated with aortic inflammation.Further research is required to elucidate the mechanisms of anthracycline-related vascular harm.
Keyphrases
- positron emission tomography
- computed tomography
- end stage renal disease
- pet ct
- pet imaging
- oxidative stress
- aortic valve
- diffuse large b cell lymphoma
- endothelial cells
- ejection fraction
- newly diagnosed
- left ventricular
- chronic kidney disease
- pulmonary artery
- peritoneal dialysis
- prognostic factors
- induced pluripotent stem cells
- atrial fibrillation
- patient reported
- pulmonary arterial hypertension