Fluid shear stress enhances T cell activation through Piezo1.
Jacob M HopeJenna A DombroskiRebecca S PerelesMaria Lopez-CavestanyJoshua D GreenleeSamantha C SchwagerCynthia A Reinhart-KingMichael R KingPublished in: BMC biology (2022)
These results demonstrate an intriguing new dynamic to T cell activation, as the circulatory system consists of different magnitudes of FSS and could have a proinflammatory role in T cell function. The results also identify a potential pathophysiological relationship between T cell activation and FSS, as hypertension is a disease characterized by abnormal blood flow and is correlated with multiple autoimmune diseases.