Impact of preoperative treatment on the CINSARC prognostic signature: translational research results from a phase 1 trial of the German Interdisciplinary Sarcoma Group (GISG 03).

Jens JakobTom LesluyesAnna Simeonova-ChergouFrederik WenzPeter HohenbergerFrederic ChibonSophie Le Guellec

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2019)

Concurrent radiation therapy and sunitinib leads to diverging results of prognostic gene array testing in a relevant proportion of sarcoma patients. These changes may reflect tumor heterogeneity, local treatment effects, or prognostic changes of the disease. Caution is advised in the selection of samples and interpretation of test results.

Keyphrases

radiation therapy
end stage renal disease
ejection fraction
newly diagnosed
patients undergoing
prognostic factors
gene expression
squamous cell carcinoma
locally advanced
mass spectrometry
copy number