Increased gene expression variability in BRCA1-associated and basal-like breast tumours.
George A R WigginsMichael A BlackAnita DunbierArthur E Morley-Bunkernull nullJohn F PearsonLogan C WalkerPublished in: Breast cancer research and treatment (2021)
Our novel results describe a state of increased gene expression variability in BRCA1-related and basal-like breast tumours. Furthermore, genes with increased variability may be driven by changes in DNA occupancy of epigenetic effectors. The variation in gene expression is replicable and led to the identification of novel associations between genes and disease phenotypes.