DNA Methylation Status of the Interspersed Repetitive Sequences for LINE-1, Alu, HERV-E, and HERV-K in Trabeculectomy Specimens from Glaucoma Eyes.
Sunee ChansangpetchSasiprapa PrombhulVisanee TantiseviPimpayao SodsaiAnita ManassakornNattiya HirankarnShan C LinPublished in: Journal of ophthalmology (2018)
The trabeculectomy sections had relative DNA hypomethylation of Alu in all glaucoma subtypes and relative DNA hypermethylation of HERV-K in POAG patients. These methylation changes may lead to the fibrotic phenotype in the trabecular meshwork.
Keyphrases
- dna methylation
- circulating tumor
- end stage renal disease
- genome wide
- ejection fraction
- cell free
- single molecule
- newly diagnosed
- chronic kidney disease
- gene expression
- prognostic factors
- optical coherence tomography
- cataract surgery
- high frequency
- systemic sclerosis
- bone mineral density
- body composition
- patient reported
- ultrasound guided