Philadelphia chromosome-positive B-lymphoblastic lymphoma successfully treated with chemotherapy regimen containing imatinib: A rare case report and literature review.
Xiaoning LiWeijie CaoSuping ZhangLi LiYingmei LiZhongxing JiangDingming WanJifeng YuPublished in: Medicine (2021)
In B-LBL, a BCR/ABL mutation can happen in some of these patients. It is important to guide the pathologist to perform appropriate gene mutation detection, in addition to routine Immunohistochemistry test, to ensure an accurate diagnosis and use the targeted agent for treatment. According to the literature and our results, it seems that intensive chemotherapy plus TKI regimen is effective in inducing complete remission, and allo-SCT should be used as a long-term strategy.
Keyphrases
- chronic myeloid leukemia
- acute lymphoblastic leukemia
- tyrosine kinase
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- high resolution
- peritoneal dialysis
- rheumatoid arthritis
- gene expression
- prognostic factors
- systemic lupus erythematosus
- squamous cell carcinoma
- copy number
- radiation therapy
- disease activity
- drug delivery
- mass spectrometry
- advanced non small cell lung cancer
- smoking cessation
- loop mediated isothermal amplification
- chemotherapy induced