Glial activation in pain and emotional processing regions in the nitroglycerin mouse model of chronic migraine.
Haley C CropperCatherine M ConwayWhitney WycheAmynah Amir Ali PradhanPublished in: Headache (2024)
Immunohistochemical analysis suggests that, at the time point tested, immunoreactivity of GFAP+ astrocytes, but not Iba1+ microglia, changes in response to chronic migraine-associated pain. Additionally, there do not appear to be significant differences between males and females in GFAP+ or Iba1+ cells across the four brain regions analyzed.
Keyphrases
- neuropathic pain
- chronic pain
- mouse model
- pain management
- induced apoptosis
- spinal cord
- spinal cord injury
- cell cycle arrest
- inflammatory response
- white matter
- resting state
- signaling pathway
- oxidative stress
- endoplasmic reticulum stress
- cell death
- drug induced
- brain injury
- cerebral ischemia
- functional connectivity
- postoperative pain