Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-like-3, and Risk of Heart Failure in Elders.
Jorge R KizerSheena PatelPeter GanzAnne B NewmanShalender BhasinSe-Jin LeePeggy M CawthonNathan LeBrasseurSanjiv J ShahBruce M PsatyRussell P TracySteven R CummingsPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
Among older adults, serum follistatin and FSTL-3, but not GDF-11 or GDF-8, were associated with incident HF. These findings do not support the concept that low serum levels of total GDF-11 or GDF-8 contribute to HF late in life, but do implicate transforming growth factor-βsuperfamily pathways as potential therapeutic targets.