Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis.

Junjie CenYanping LiangYong HuangYihui PanGuannan ShuZhousan ZhengXiaozhong LiaoMi ZhouDanlei ChenYong FangWei ChenJunhang LuoJiaxing Zhang

Published in: Molecular cancer (2021)

Our data indicates, for the first time, an essential role for the circSDHC/miR-127-3p/CDKN3/E2F1 axis in RCC progression. Thus, circSDHC has potential to be a new therapeutic target in patients with RCC.

Keyphrases

renal cell carcinoma
signaling pathway
electronic health record
big data
machine learning
data analysis
climate change
artificial intelligence