Risk stratification of oxaliplatin induced peripheral neurotoxicity applying electrophysiological testing of dorsal sural nerve.

Paola AlbertiEmanuela RossiAndreas A ArgyriouHaralabos P KalofonosChiara BrianiMario CacciavillaniMarta CampagnoloJordi BrunaRoser VelascoMarina E CazzanigaDiego CortinovisMaria G ValsecchiGuido Cavaletti

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)

We demonstrated the role that neurophysiology may play in clinical trials as an early surrogate marker that can predict OXAPN development at the end of treatment. Specifically, we propose abnormal dorsal sural sensory nerve testing as an early biomarker in identifying patients at high risk of eventually developing OXAPN.

Keyphrases

spinal cord
clinical trial
neuropathic pain
peripheral nerve
high glucose
spinal cord injury
drug induced
oxidative stress
study protocol