Cerebral glucagon-like peptide-1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice.

Chuanxiang LvShuai HanZhuang ShaMingqi LiuShiying DongChunyun ZhangZean LiKang ZhangShouyong LuZhiyang XuLi BieRongcai Jiang

Published in: CNS neuroscience & therapeutics (2023)

Cerebral GLP-1R activation can effectively ameliorate neuropathological changes and cognitive impairment following TBI; the underlying mechanism could involve the repair of the glymphatic system damaged by TBI.

Keyphrases

traumatic brain injury
cognitive impairment
subarachnoid hemorrhage
severe traumatic brain injury
cerebral ischemia
high fat diet induced
cerebral blood flow
mouse model
type diabetes
brain injury
insulin resistance