Calcineurin Inhibition in Deceased Organ Donors: A Systematic Review and Meta-analysis of Preclinical Studies.
Frédérick D'AragonWilliam RousseauRuth BreauDaniel AminaeiCarole IchaiGordon J BoydKaren E A BurnsHéloïse CardinalFrançois-Martin CarrierMichaël ChasséProsanto ChaudhurySonny DhananiShane W EnglishAnne Julie FrenetteSteven HannaGregory KnollFrançois LauzierSimon OczkowskiBram RochwergKhaled ShamseddinMarat SlessarevDarin TreleavenAlexis F TurgeonMatthew J WeissMarkus SelznerMaureen O MeadePublished in: Transplantation direct (2023)
Although this compendium of animal experiments suggests that donor preconditioning with CNIs may improve early kidney graft function, the limited ability to reproduce a true clinical environment in animal experiments and to assess for risk of bias in these experiments is a serious weakness that precludes current clinical application.