Retrospective Study on the Association of Human Herpesvirus Reactivation with Severe DRESS: A Description of Blood and Skin Reactivations.

C Marcombes Saskia Ingen Housz Oro Frédéric DezoteuxD Staumont-SalléB MilpiedF TetartN de ProstS FouratiNicolas OrtonneF KasimirB K PrustyV Descampsnull null

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

We confirmed the high rate of HHV-6 reactivation in severe DRESS and demonstrated cutaneous HHV-6 reactivation using small non-coding transcripts (HHV-6 miR-aU14), which preceded viral PCR positivity in blood. These results suggest that HHV-6 reactivation during DRESS may start in skin. Furthermore, search for miR-aU14 in skin biopsy could become a useful diagnostic tool for early detection of HHV-6 reactivation.

Keyphrases

cell proliferation
long non coding rna
soft tissue
wound healing
endothelial cells
long noncoding rna
early onset
sensitive detection
sars cov
ultrasound guided
quantum dots