A genome-wide association study of radiotherapy induced toxicity in head and neck cancer patients identifies a susceptibility locus associated with mucositis.

Line M H SchackElnaz NaderiLaura FachalLeila DorlingCraig LuccariniAlison M Dunningnull nullnull nullEnya H W OngMatthew Chin Heng ChuaJohannes A LangendijkBehrooz Z Alizadeh Jens OvergaardJesper Grau EriksenChristian Nicolaj AndreassenJan Alsner

Published in: British journal of cancer (2022)

This first exploratory GWAS in European cohorts of HNC patients identified and replicated a risk locus for mucositis. A larger Meta-GWAS to identify further risk variants for RT-induced toxicity in HNC patients is warranted.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
genome wide association study
prognostic factors
peritoneal dialysis
early stage
radiation induced
radiation therapy
patient reported outcomes
high glucose
copy number