Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation.

Hayley L Letson Jodie L Morris Geoffrey P Dobson

Published in: Pharmacology research & perspectives (2023)

We conclude that the trauma of surgery alone was associated with significant increases in AGP in rats, compared to a contrasting decrease in pigs. Higher levels of plasma AGP in pigs prior to hemorrhagic shock is consistent with the higher ALM doses required to resuscitate pigs compared with rats.

Keyphrases

minimally invasive
cardiac arrest
trauma patients
coronary artery bypass
emergency department
stem cells
cardiopulmonary resuscitation
coronary artery disease
adverse drug
percutaneous coronary intervention