Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus Aspergillus carneus GXIMD00543.
Chun-Ju LuLi-Fen LiangGeng-Si ZhangHai-Yan LiChun-Qing FuQin YuDong-Mei ZhouZhi-Wei SuKai LiuCheng-Hai GaoXin-Ya XuYong-Hong LiuPublished in: Marine drugs (2024)
Six benzophenone derivatives, carneusones A-F ( 1 - 6 ), along with seven known compounds ( 7 - 13 ) were isolated from a strain of sponge-derived marine fungus Aspergillus carneus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds 5 , 6 , and 8 exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC 50 values of 34.6 ± 0.9, 20.2 ± 1.8, and 26.8 ± 1.7 μM, while 11 showed potent effect with an EC 50 value of 2.9 ± 0.1 μM.
Keyphrases
- lps induced
- inflammatory response
- molecular dynamics
- induced apoptosis
- cell cycle arrest
- molecular docking
- density functional theory
- electronic health record
- cell wall
- molecular dynamics simulations
- high intensity
- high resolution
- monte carlo
- machine learning
- cell death
- immune response
- oxidative stress
- data analysis
- anti inflammatory
- artificial intelligence