Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.
Narges Zare MehrjardiMarek MolcanyiFiruze Fulya HatayMarco TimmerEbrahim ShahbaziJustus P AckermannStefan HermsStefanie Heilmann-HeimbachThomas F WunderlichNora ProchnowAiden HaghikiaAngelika LampertJürgen HeschelerEdmund A M NeugebauerHossein BaharvandTomo ŠarićPublished in: Cell proliferation (2020)
These results demonstrate that, independently of ZFN-editing, hiPSC-NSCs have a propensity for acquiring dup(1)q and this aberration results in increased proliferation which might compromise downstream hiPSC-NSC applications.