Dexmedetomidine affects the NOX4/Nrf2 pathway to improve renal antioxidant capacity.
Haotian YangYongping ChenZhiqiang WangYuxiang HuangZhigang MaYue ZouJiaqiang DongHong ZhangMingdong HuoMingzhe LvXuesong LiuGuohua ZhangShuang WangKun YangPeng ZhongBotao JiangYuhong KouZhifeng ChenPublished in: The Journal of pharmacy and pharmacology (2024)
The findings suggest that DEX treatment during acute stress can impact the NOX4/Nrf2/HO-1/NQO1 signaling pathway and inhibit oxidative stress, thereby preventing acute stress-induced kidney injury. Additionally, DEX shows promise for clinical applications in stress syndromes.
Keyphrases
- stress induced
- oxidative stress
- liver failure
- signaling pathway
- respiratory failure
- induced apoptosis
- pi k akt
- drug induced
- aortic dissection
- dna damage
- reactive oxygen species
- diabetic rats
- ischemia reperfusion injury
- epithelial mesenchymal transition
- cardiac surgery
- cell proliferation
- extracorporeal membrane oxygenation
- combination therapy
- intensive care unit
- endoplasmic reticulum stress
- replacement therapy
- heat shock protein