Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX.

Amikar SehdevOlumide GbolahanBrad A HancockMelissa StanleySafi ShahdaJun WanHoward H WuMilan RadovichBert H O'Neil

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

In a single institution, retrospective study, we found that the presence of DDR gene mutations are associated with improved OS in PDAC patients treated with FOLFIRINOX.

Keyphrases

dna damage
locally advanced
dna repair
squamous cell carcinoma
rectal cancer
small cell lung cancer
oxidative stress
radiation therapy
copy number
free survival