Whole genome sequencing and genotyping Klebsiella pneumoniae multi-drug resistant hospital isolates from Western Kenya.
Victor DindaAndrew Nyerere Kimang'aDaniel KariukiAnthony Wawire SifunaThomas James O'BrienMartin WelchOleg N RevaPublished in: Access microbiology (2024)
Our data suggest that the evolutionary success of ST147 may be linked with the acquisition of broad host-range plasmids, and their propensity to accrue AMR and virulence determinants. Although ST147 is a dominant lineage in many countries worldwide, it has not been previously reported as prevalent in Africa. Our data suggest an influx of new nosocomial pathogens with new virulence genes into African hospitals from other continents.
Keyphrases
- klebsiella pneumoniae
- multidrug resistant
- drug resistant
- escherichia coli
- gram negative
- acinetobacter baumannii
- antimicrobial resistance
- genome wide
- pseudomonas aeruginosa
- electronic health record
- staphylococcus aureus
- biofilm formation
- healthcare
- big data
- south africa
- high throughput
- cystic fibrosis
- machine learning
- emergency department
- single cell
- adverse drug
- genetic diversity