RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.

Kosuke OkazakiHiroaki KatoTetsushi IidaKaori ShinmyozuJun-Ichi NakayamaYota MurakamiTakeshi Urano

Published in: Epigenetics & chromatin (2018)

Our results suggest that the Hsps Hsp90 and Mas5 contribute to RNAi-dependent heterochromatin assembly. In particular, Mas5 appears to be required to stabilize Tas3 in vivo. We infer that impairment of Hsp90 and Hsp40 also may affect the integrity of the epigenome in other organisms.

Keyphrases

heat shock
heat shock protein
heat stress
oxidative stress
gene expression