Uncovering Infant Group B Streptococcal (GBS) Disease Clusters in the United Kingdom and Ireland Through Genomic Analysis: A Population-based Epidemiological Study.

Simon Michael CollinNatalie GrovesCatherine O'SullivanElita JauneikaiteDarshana PatelRobert CunneyMary MeehanArlene ReynoldsAndrew SmithDiane LindsayLorraine DohertyEleri DaviesVictoria ChalkerPeter LambBaharak AfsharSooria BalasegaramJuliana CoelhoDerren ReadyColin S BrownAndroulla EfstratiouKirsty Le DoareShiranee SriskandanPaul T HeathTheresa Lamagni

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Approximately 1 in 12 late-onset infant iGBS cases were part of a hospital cluster. Over half of the clusters were previously undetected, emphasizing the importance of routine submission of iGBS isolates to reference laboratories for cluster identification and genomic confirmation.

Keyphrases

late onset
early onset
healthcare
clinical practice
copy number
genetic diversity
adverse drug