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Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammation.

Danqi HuangXiuting LiuXun GaoChun Kit ChoiGiovanni GiglioLuay FarahTing-Fan LeungKatie Ching-Yau WongLea Ling-Yu KanJeffrey Wing-Heung ChongQing-Jun MengJinyue LiaoPhyllis Fung-Yi CheungChun-Kwok Wong
Published in: Allergy (2024)
METRNL can bind to KIT receptor and subsequently alleviate the allergic inflammation of AD by inhibiting the expansion of immune cells, and downregulating inflammatory gene expression by regulating the level of active WNT pathway molecule β-Catenin.
Keyphrases
  • atopic dermatitis
  • oxidative stress
  • gene expression
  • cell proliferation
  • dna methylation
  • stem cells
  • epithelial mesenchymal transition
  • signaling pathway
  • mouse model