Analysis of porcine body size variation using re-sequencing data of miniature and large pigs.
Christian ReimerC-J RubinA R SharifiN-T HaS WeigendK-H WaldmannO DistlS D PantM FredholmM SchlatherH SimianerPublished in: BMC genomics (2018)
The resulting set of genes in putative sweep regions implies that the genetic background of body size variation in pigs is polygenic rather than mono- or oligogenic. Identified genes suggest alterations in metabolic functions and a possible insulin resistance to contribute to miniaturization. A size QTL located within the sweep on chromosome X, with an estimated effect of 3% on body length, is comparable to the largest known in pigs or other species. The androgen receptor AR, previously known to influence pig performance and carcass traits, is the most obvious potential candidate gene within this region.
Keyphrases
- genome wide
- copy number
- insulin resistance
- genome wide identification
- dna methylation
- type diabetes
- bioinformatics analysis
- adipose tissue
- metabolic syndrome
- genome wide analysis
- electronic health record
- high fat diet
- single cell
- big data
- gene expression
- skeletal muscle
- human health
- high density
- genome wide association study