KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer.
Seo-Hyun ChoiJin K KimChin-Tung ChenChao WuMichael R MarcoFrancisco M BarrigaKevin O'RourkeRaphael PelossofXuan QuQing ChangElisa de StanchinaJinru ShiaJ Joshua SmithFrancisco Sanchez-VegaJulio Garcia-AguilarPublished in: Molecular cancer research : MCR (2022)
Knocking-out ITGB4, which is overexpressed in KRAS-mutant colorectal cancer and promotes tumor aggressiveness, diminishes local invasiveness and rates of pulmonary metastasis.