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Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts.

Christoph H MayrArunima SenguptaSara AsgharpourMeshal AnsariJeanine C PestoniPaulina OgarIlias AngelidisAndreas LiontosJosé Alberto Rodriguez-CastilloNiklas J LangMaximilian StrunzDiana Porras-GonzalezMichael GerckensDe Sadeleer LaurensBettina OehrleValeria Viteri-AlvarezIsis E FernandezMichelle TallquistMartin IrmlerJohannes BeckersOliver EickelbergGabriel Mircea StoleriuJürgen BehrNikolaus KneidingerWim A WuytsRoxana Maria WasnickAli Oender YildirimKatrin AhlbrechtRory Edward MortyChristos SamakovlisFabian J TheisGerald BurgstallerHerbert B Schiller
Published in: The European respiratory journal (2024)
Our study reveals the convergence of spatially and transcriptionally distinct fibroblast lineages into transcriptionally uniform myofibroblasts and identifies SFRP1 as a modulator of TGFβ1-driven fibroblast phenotypes in fibrogenesis. These findings are relevant in the context of therapeutic interventions that aim at limiting or reversing fibroblast foci formation.
Keyphrases
  • wound healing
  • transforming growth factor
  • gene expression
  • diabetic rats
  • drug induced
  • dna methylation
  • signaling pathway