MiR-152-5p suppresses osteogenic differentiation of mandible mesenchymal stem cells by regulating ATG14-mediated autophagy.
Shaoming LiLing GaoWeidong ZhangYanbin YuJingjing ZhengXiao LiangShanshan XinWenhao RenKeqian ZhiPublished in: Stem cell research & therapy (2022)
Our data suggest that miR-152-5p is the first identified to regulate osteogenic differentiation by directly targeting autophagy-related protein ATG14 and regulating oxidative stress and therapeutic inhibition of miR-152-5p may be an efficient anabolic strategy for osteoporosis.
Keyphrases
- mesenchymal stem cells
- oxidative stress
- signaling pathway
- cell death
- endoplasmic reticulum stress
- umbilical cord
- bone marrow
- induced apoptosis
- postmenopausal women
- dna damage
- ischemia reperfusion injury
- electronic health record
- bone mineral density
- big data
- cancer therapy
- stem cells
- machine learning
- artificial intelligence
- heat shock protein