Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
Sok Lin FooKarishma SachaphibulkijCorinne L Y LeeGracemary L R YapJianzhou CuiThiruma ArumugamLina Hsiu Kim LimPublished in: Breast cancer research : BCR (2022)
The present study uncovered a network encompassing autocrine/paracrine ANXA1 signaling between metastatic mammary cancer cells and microglia that drives microglial recruitment and activation. Inhibition of ANXA1 and/or its receptor may be therapeutically rewarding in the treatment of breast cancer and secondary metastasis to the brain.