Association of polymorphisms in ZFHX1B, KCNQ5 and GJD2 with myopia progression and polygenic risk prediction in children.
Guy L J ChenFen Fen LiShi Yao LuXiu Juan ZhangKa Wai KamShu Min TangPancy Os TamWilson Wk YipAlvin L YoungClement Chee Yung ThamChi Pui PangJason C S YamPublished in: The British journal of ophthalmology (2021)
In this study, multi-tiered evidence suggested SNPs in ZFHX1B, KCNQ5 and GJD2 as risk factors for myopia progression in children. Additional attention and appropriate interventions should be given for myopic children with high-risk PRS as defined by GJD2 rs524952, KCNQ5 rs7744813 and ZFHX1B rs13382811.