Palladium-Catalyzed sp2-sp3 Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes.
Sheng ZhangJinfang CaiYoshinori YamamotoMing BaoPublished in: The Journal of organic chemistry (2017)
Palladium-catalyzed remote sp2-sp3 coupling reaction of chloromethylarenes with allyltrimethoxysilane is described in this work. The allylation reaction regioselectively occurred on the para-positions of 1-(chloromethyl)naphthalenes and benzyl chlorides to form new C(sp2)-C(sp3) bonds. The reaction proceeds smoothly under mild conditions to produce allyl arenes in moderate to excellent yields.
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