Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma.

Laura S RozekShama ViraniEmily L BellileJeremy M G TaylorMaureen A SartorKatie R ZarinsA ViraniC CoteFrancis P WordenMark E Prince MarkScott A McLeanSonya A DuffyGeorge H YooNabil F SabaDong M ShinOmer KucukGregory T Wolf

Published in: Nutrition and cancer (2019)

This is the first demonstration of in vivo increases in tissue-specific global methylation associated with soy isoflavone intake in patients with HNSCC. Prior associations of LINE-1 hypomethylation with genetic instability, carcinogenesis, and prognosis suggest that soy isoflavones maybe potential chemopreventive agents in HNSCC.

Keyphrases

genome wide
dna methylation
copy number
risk assessment