Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation.
Konstantinos ZifkosMagdalena L BochenekRajinikanth GogirajuStephane RobertDenise G PedrosaKlytaimnistra KiouptsiKateryna MoikoMathias WagnerFelix MahfoudPhilippe PonceletThomas MunzelWolfram RufChristian ReinhardtLaurence Panicot-DuboisChristophe DuboisKatrin SchäferPublished in: Circulation research (2024)
Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.
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