Capsaicin inhibits lipopolysaccharide-induced adrenal steroidogenesis by raising intracellular calcium levels.

Leonardo G B FerreiraJessika P PrevattoHercules R FreitasRicardo A M ReisPatrícia M R SilvaMarco A MartinsRobson X FariaVinicius de Frias Carvalho

Published in: Endocrine (2019)

These findings suggest that capsaicin inhibits corticosterone production induced by LPS by acting directly on adrenal cells producing glucocorticoids, in a mechanism probably associated with induction of a cytoplasmic calcium increase in these cells.

Keyphrases

lipopolysaccharide induced
induced apoptosis
inflammatory response
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death
cell proliferation
anti inflammatory
reactive oxygen species
pi k akt