Genetic risk of prostate cancer in Ugandan men.
Zhaohui DuAlexander LubmawaSusan GundellPeggy WanCissy NalukengeProscovia MuwangaMoses LutaloDeborah NanserekoOlivia NdaruhutseMolly KatukuRosemary Nassanganull nullFrank AsiimweBenon MasabaSam KaggwaDan NamuguziVicky KidduGeorge MutemaDavid V ContiAsiimwe LukeKuteesa JobDabanja M HenryChristopher A HaimanStephen WatyaPublished in: The Prostate (2018)
The ∼100 known PCa risk variants were shown to effectively stratify PCa risk in Ugandan men, with 10% of men having a >4-fold increase in risk. The 8q24 risk region was also found to be a major contributor to PCa risk in Ugandan men, with the African ancestry-specific risk variant rs72725854 estimated to account for 12% of PCa in this population.