P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.

Yin-Wei ChengFa-Min ZengDa-Jia LiShao-Hong WangJian-Zhong HeZhen-Chang GuoPing-Juan NieZhi-Yong WuWen-Qi ShiBing WenXiu-E XuLian-Di LiaoZhi-Mao LiJian-Yi WuJun ZhanHong-Quan ZhangZhi-Jie ChangKai Zhang Li-Yan Xu En-Min Li

Published in: Cancer communications (London, England) (2021)

Fascin interacts directly with PCAF and is acetylated at lysine 471 in ESCC cells. Fascin-K471 acetylation suppressed ESCC cell migration and tumor metastasis by reducing filopodium formation through the impairment of its actin-bundling activity.

Keyphrases

cell migration
induced apoptosis
cell cycle arrest
histone deacetylase
oxidative stress
amino acid
signaling pathway
cell death
binding protein
cell proliferation