APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers.
Lochlan J FennellAlexandra M KaneCheng LiuDiane McKeoneWinnie FernandoChang SuCatherine BondSaara JamiesonTroy DumenilAnn-Marie PatchStephen H KazakoffJohn V PearsonNicola WaddellBarbara LeggettVicki L J WhitehallPublished in: Cancers (2020)
the WNT signaling axis is frequently mutated in BRAF mutant colorectal cancers. WNT16 and MEN1 may be novel drivers of aberrant WNT signaling in colorectal cancer. Co-mutation of BRAF and APC generates an extremely aggressive neoplastic phenotype that is associated with poor patient outcome.