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APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers.

Lochlan J FennellAlexandra M KaneCheng LiuDiane McKeoneWinnie FernandoChang SuCatherine BondSaara JamiesonTroy DumenilAnn-Marie PatchStephen H KazakoffJohn V PearsonNicola WaddellBarbara LeggettVicki L J Whitehall
Published in: Cancers (2020)
the WNT signaling axis is frequently mutated in BRAF mutant colorectal cancers. WNT16 and MEN1 may be novel drivers of aberrant WNT signaling in colorectal cancer. Co-mutation of BRAF and APC generates an extremely aggressive neoplastic phenotype that is associated with poor patient outcome.
Keyphrases
  • wild type
  • metastatic colorectal cancer
  • stem cells
  • cell proliferation
  • case report