Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma.

Meng LiYujie HanChaochen WangWenfeng KangWenyan JiangLei ZhangYujie Tang

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our study verifies the oncogenic role and therapeutic potential of SE-driven transcriptional dependencies of G3-MB, resulting in better understanding of its tumor biology and identification of novel SE-associated therapeutic strategies and targets.

Keyphrases

transcription factor
gene expression
heat shock
binding protein