Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.
Maria HenströmLena DiekmannFerdinando BonfiglioFatemeh HadizadehEva-Maria KuechMaren von Köckritz-BlickwedeLouise B ThingholmTenghao ZhengGhazaleh AssadiClaudia DierksMartin HeineUte PhilippOttmar DistlMary E MoneyMeriem BelheouaneFemke-Anouska HeinsenJoseph RafterGerardo NardoneRosario CuomoPaolo Usai-SattaFrancesca GaleazziMatteo NeriSusanna WalterMagnus SimrénPontus KarlingBodil OhlssonPeter T SchmidtGreger LindbergAldona DlugoszLars AgreusAnna AndreassonEmeran MayerJohn F BainesLars EngstrandPiero PortincasaMassimo BelliniVincenzo StanghelliniGiovanni BarbaraLin ChangMichael CamilleriAndre FrankeHassan Y NaimMauro D'AmatoPublished in: Gut (2016)
SI gene variants coding for disaccharidases with defective or reduced enzymatic activity predispose to IBS. This may help the identification of individuals at risk, and contribute to personalising treatment options in a subset of patients.