Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome.

Marco ConstanteGiada De PalmaJun LuJennifer JuryLiam RondeauAlberto CamineroStephen M CollinsElena F Verdu Premysl Bercik

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Treatment with S. bou improves gastrointestinal motility and anxiety-like behavior in mice with IBS+A microbiota. Putative mechanisms include effects on pain pathways, direct modulation of the microbiota, and indole production by commensal bacteria.

Keyphrases

irritable bowel syndrome
mouse model
chronic pain
pain management
neuropathic pain
white matter
resting state
multiple sclerosis
staphylococcus aureus
adipose tissue
combination therapy
metabolic syndrome
blood brain barrier
physical activity
functional connectivity
replacement therapy
wild type